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need to delete a file

are there programs out there that'll delete a file regardless if it's "in use" or not? i've had this 1 file on my HDD for quite some time but when ever i try to delete it, it says it's in use... it's 400MB and i really need to get rid of it... any suggestions?
 
Have you tried deleting it in safe mode?

What is it, anyway? I remember reading here a work around for people having trouble deleting .avi files. I'll look for it, though I'm sure someone esle knows what it is.
 
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