Study compares one twin who spent a year in space with his twin on earth. Pretty interesting findings
https://www.nytimes.com/2019/04/11/science/scott-mark-kelly-twins-space-nasa.html
NASA researchers reported that his body experienced a vast number of changes while in orbit. DNA mutated in some of his cells. His immune system produced a host of new signals. His microbiome gained new species of bacteria.
https://www.nytimes.com/2019/04/11/science/scott-mark-kelly-twins-space-nasa.html