I'm assuming your partitions are already aligned (will should be if you're on Vista/7) then you'd only need to worry about preserving alignment. Intel does offer for free download it's version of Acronis which will maintain your alignment. I'm sure Ghost will do this automatically. Sometimes just before you make the final changes you can preview in sordid detail the changes to be made. Just be sure that the starting positions or offets of each partition you have are the same or are aligned.
I'm on Win 7 Pro X64, which is installed on my Kingston 40GB. If I clone it using Norton Ghost 15 to the Intel 80GB, will the partitions remain aligned?
Also, will the 100MB Win 7 partition be affected? I've read of some people's systems not being able to boot after cloning due to this partition.