Most . . . nevermind . . . none of you have a clue how Big Pharma operates in America. Price controls will not cripple R&D and most of the "lifesaving therapies" from Big Pharma are being deserted (vaccines, antibiotics) in favor of "lifestyle" medications. As a physician I would say pharmacogenomics (learning how to give the right drug based on a persons genotype/phenotype) is a much better investment than the next generation erection pill. It's perfectly fine for the government to fund pharmacogenomic research much like it's funded Big Pharma through basic science research, graduate/post graduate training for scientists, and Medicare/Medicaid/VA.
How ridiculous has the system become?
news
NEW YORK (Reuters) - Four prominent medical organizations warned on Tuesday that a widely prescribed class of antipsychotic drugs increase the risk of diabetes, echoing concerns raised by U.S. regulators and researchers.
The American Diabetes Association, American Psychiatric Association, American Association of Clinical Endocrinologists (news - web sites) and the North American Association for the Study of Obesity joined forces in a statement published in the February issue of Diabetes Care.
Now in response to such an unambiguous iatrogenic effect . . . the drug company response . . .
Zyprexa has annual sales of some $4 billion and accounts for about half Lilly's profit. The company said it is not clear whether there is a direct link between its drug and diabetes.
Curiously, though Lilly has funded several intervention studies trying to prevent metabolic dysregulation secondary to olanzapine (Zyprexa). And the rumor mill is that Lilly will throw big money at researchers working on effective therapies. So a great drug for psychosis but a serious side effect. Ziprasidone (Geodon) is sold by the evil empire . . . others call them Pfizer. Not only is ziprasidone equally effective but it doesn't cause metabolic dysregulation in adults (but it makes kids fat . . . oh well). When ziprasidone was released the drug reps from some unnamed company . . . LILLY . . . would troll the hospitals, clinics, and offices telling MDs that ziprasidone was unsafe b/c it could potentially cause a fatal heart arrhythmia . . . which turned out to be as reliable as WMD stockpiles in Iraq. Pfizer is getting a decent share of the pie these days though; about $1.5-2B a year globally.
The best though was a statement by an executive at GlaxoSmithKlineBeecham who finally told the truth that every decent doctor has known since stumbling out of medical school . . . many if not MOST medications are insufficient as primary therapy. Despite having higher copays for office visits and medication . . . antipsychotics and antidepressants . . . as classes are the most effective drugs on the market. In the meantime, Americans spend MANY billions of dollars on medications that are providing nominal benefit. The most responsible party is the medical profession but the lazy, uncooperative, ill-informed patients, profit-driven drug company, and idiotic, duplicitous politicians are scarcely better.
In sum, the drugs we need most (better, more vaccines and better, more antibiotics) are not being made b/c there's not ENOUGH profit. The drugs that are less important (PDEIs . . . think one-eyed yogurt shooter) and less effective (AchEI . . . think Reagan) keep rolling out of Big Pharma's plants.