Beyond '05?
Nothing.
Before '05?
Damn near everything.
And while I love it for the story and characters it was not the best game ever. My measure of a good game is the GAMEPLAY!
Which people laugh at now but back in the good old days thats what we liked to do with our games, play them.
Nowadays its more like those interactive movies they used to have for Sega CD and CDi. Which is funny because those things bombed horribly. Who knew it would be the wave of the future?
Mass Effect has a lot of that because they werent allowed to make a fun game for all the idiot console fanboys. Its still OK, and the epic story is enough to make you play it once. I seriously hope they fix the game play in ME2. Either improve the shooting action or, better yet, make it command-based like KOTOR. They also need to fix the inventory and upgrading. It might be acceptable for a gamepad controller and limited resolution, but its not good enough for a mouse & keyboard.