I travel a lot, and a laptop just doesn't cut it. I have the following:
5x 3.5inch drives
1x 5.25inch drive
Rampage II Gene
Noctua NH-U12
6 sticks of Kingston HyperX T1, (with the tall heat sinks)
Asus 5770 CuCore
Seasonic 750 gold PSU
I got it all to fit in a small no-name box that's 7.5x14x16 inches high, and it fits inside a carry-on bag with wheels. I can fit it in the overhead compartment on flights.
I tried to get a Silverstone TJ08, because it would also fit in the overhead, and it looks like a great case. But I was in Turkey at the time, and couldn't find one. The Silverstone is a liitle bigger than the case I ended up with but mine only cost $20. I have three Noctua 120mm fans- one in front, one pushing out the back, and one strapped to the cooler. I don't have enough room for the second fan on the cooler, due to the tall RAM, so I put tape around the cooler fins to force all the air to go through the cooler from the single pulling fan in the back. The rear fan lines up with the cooler fan, with only about a half inch clearance, so it's kind of like push/pull still- but not really. I have another 80mm fan blowing on the NB, and I can run my i7 920 at 3.8GHz without getting too hot. I put some plastic inserts into the top of the cooler, and drilled matching holes in the side of the case to support the cooler with a couple screws. I was concerned about the stress on the MB with all that arm sticking out so far while traveling. I intend to get a couple SSDs, and have room for them, but will have to mount them with velcro.
If you consider this rout, I would recommend Corsairs H50. It's very small for an efficient cooler, and would not stress the board like a big air cooler can. No need to mess with supporting the top of the cooler. With a small case you will have trouble with two GPUs. The ones you have will likely be too long at 10.5 inches, but the GTX 460s should fit. They're shorter than the 5770 I have. With two cards, you would probably have to drill holes in the bottom of the case to get air to the bottom card. Also, a modular PSU makes for a clean wire job, which is necessary for good airflow in a small enclosure.