As stardrek said, solid state components are in no danger really.. The computer should go obsolote before it breaks. However, the PSU and hard drives should be a factor. Hard drives should be set to hibernate when not in use. They do have a MTBF. PSUs as well, I'm guessing it's the fan that is the rated one. However, if you look at high end ones from zippy/emac, or delta, they are rated for MTBF.
Also, make sure you have surge protection and UPS to handle brownouts. That's pretty important. That'll fry your computer for sure if you get a surge and it's on without protection.