I have a VX Revolution thrown in my laptop backpack for use on the road. I'm actually thinking about going out to buy two or three more, just to keep as spares, for when my current mice inevitably die. I forgot that Best Buy is running a sale on them this week... /me makes note to go to Best Buy this afternoon.
While it will work without the Logitech Software installed, I personally do prefer having it installed, because that allows me to control what the buttons do. I honestly can't remember which customizations I made, but I did change a few things on my laptop's VX profile.
Good luck, and let us know what you think of it.
