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Is Tylenol bad after a night of drinking?
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This is true when we are talking about 8-12 drinks. For 12+ drinks we need to go a little more proactive.
Zerohm's guild to never having a hangover:
1. Don't drink too many drinks with tons of sugar e.g. Daiquiris or Ciders
2. Stay up at least an hour after your last drink and consume lots of water and a big Gatorade, maybe even a banana for potassium. Vitamins may also help if taken before you go to bed.
3. Take an Ibuprofen right before you go to bed.
4. Sleep for at least 6 hours and you'll feel fine no matter how much you had to drink.
You might still be drunk when you wake up, but you won't feel nearly as bad 😛
SacrosanctFiend
Diamond Member
No. Acetaminophen overdose is the leading cause of liver failure. Look at a list of all medicines that contain acetaminophen and combine acetaminophen with other drugs (it contains over 100 medications), then realize people can combine multiple medications. Then realize that many of the cases where hepatoxicity and acute liver failure occur are from attempted suicides with acetaminophen. If you stay within the recommended dosage, the risk of hepatoxicity is extremely small. "Tylenol is the leading cause of liver failure" is incorrect.
Amused
Elite Member
http://www.medicinenet.com/tylenol_liver_damage/article.htm
For the average healthy adult, the recommended maximum dose of acetaminophen over a 24 hour period is four grams (4000 mg) or eight extra-strength pills. (Each extra-strength pill contains 500 mg and each regular strength pill contains 325 mg.) A person who drinks more than two alcoholic beverages per day, however, should not take more than two grams of acetaminophen over 24 hours, as discussed below. For children, the dose is based on their weight and age, and explicit instructions are given in the package insert. If these guidelines for adults and children are followed, acetaminophen is safe and carries essentially no risk of liver injury.
On the other hand, a single dose of 7 to 10 grams of acetaminophen (14 to 20 extra-strength tablets) can cause liver injury in the average healthy adult. Note that this amount is about twice the recommended maximum dose for a 24 hour period. In children, a single dose of 140 mg/kg (body weight) of acetaminophen can result in liver injury. Amounts of acetaminophen, however, as low as 3 to 4 grams in a single dose or 4 to 6 grams over 24 hours have been reported to cause severe liver injury in some people, sometimes even resulting in death. It seems that certain individuals, for example, those who regularly drink alcohol, are more prone than others to developing acetaminophen-induced liver damage. To understand this increased susceptibility in some people, it is useful to know how acetaminophen is processed (metabolized) in the liver and how the drug causes liver injury.
SacrosanctFiend
Diamond Member
- Susan E Farrell, MD, Director of Student Programs, Assistant Professor of Medicine (Emergency Medicine), Department of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School
TraumaRN
Diamond Member
Dang just as I pulled it up from our Micromedex from work you beat me to it....by the way maybe if they told people what they have to take to reverse acetaminophen toxicity less people would try to suicide with it....God that stuff is utterly vile...rotten eggs smell like candy in comparison
SacrosanctFiend
Diamond Member
Activated charcoal or NAC?
Both tylenol, advil or aspirin are all perfectly safe for use for relief of a hangover. Most over the counter hangover remedies are actually based on tylenol (acetaminophen) because it is probably safer than the others (but the difference is extremely slight).
However, the key thing to remember about tylenol is that it is extremely dangerous in *overdose*. Accidentally taking a double dose, or taking more than 4 doses in 24 hours - is potentially damaging to the liver. While most healthy people would be unlikely to have problems with 1 double dose, or 1 extra dose in a day on a single occasion - this is not the case, if someone is a regular drinker of alcohol. Someone who drinks alcohol every day (or most days) has altered liver biochemistry which is much more sensitive to tylenol than normal.
The thing to remember is that it's not the alcholol that makes the tylenol more toxic - it's a side effect of the liver having to process alcohol on a daily (or frequent) basis. Someone, who is normally teetotal, but goes on a drinking binge - is not at high risk of tylenol overdose.
Someone who is sensitive to tylenol can get potentially fatal liver damage from just a couple of double doses. Again, remember that most ready made remedies contain tylenol - and you can see that there is the potential for people to accidentally get serious overdoses.
However, the key thing to remember about tylenol is that it is extremely dangerous in *overdose*. Accidentally taking a double dose, or taking more than 4 doses in 24 hours - is potentially damaging to the liver. While most healthy people would be unlikely to have problems with 1 double dose, or 1 extra dose in a day on a single occasion - this is not the case, if someone is a regular drinker of alcohol. Someone who drinks alcohol every day (or most days) has altered liver biochemistry which is much more sensitive to tylenol than normal.
The thing to remember is that it's not the alcholol that makes the tylenol more toxic - it's a side effect of the liver having to process alcohol on a daily (or frequent) basis. Someone, who is normally teetotal, but goes on a drinking binge - is not at high risk of tylenol overdose.
Someone who is sensitive to tylenol can get potentially fatal liver damage from just a couple of double doses. Again, remember that most ready made remedies contain tylenol - and you can see that there is the potential for people to accidentally get serious overdoses.
Probably methionine. I've never found NAC to have a particularly noticeable smell (especially the IV preparation needed for acetaminophen toxicity).
However, methionine (tablets) which can be used for acetaminophen toxicity smell extremely strongly. The best way I can describe it is "rotting cabbages".
SacrosanctFiend
Diamond Member
Is there an advantage of methionine over NAC? I've never seen methionine used for an APAP overdose.
No real advantage over NAC. It's a second line option, if NAC is contraindicated or not tolerated. It's also an oral preparation (we don't use oral NAC here).
Only used it once, after someone had a rather impressive flushing reaction to IV NAC. (Although technically not a significant reaction, I wasn't going to try my luck by suggesting that the IV continute).
SacrosanctFiend
Diamond Member
The best I could find was a paper by Alsalim and Fadel. That research found that IV NAC was better. So I wondered if there were any properties of methionine that would cause one to choose it over NAC.
TraumaRN
Diamond Member
Possibly because it's an amino acid....less chance of allergic reaction such as Mark R was referring to? It's probably a question of effectiveness....like morphine and codeine...they both take away pain but morphine is more effective in treating it and in smaller doses(if given IV push)
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