Yeah, should work.
The x-530s will only operate in 2.1 though unless you get an adapter to do stereo surround (vs. true surround). It might have come with the set already and be called a game adapter or something (takes a stereo analog signal and sends it out to all the speakers so they all play, but it's not really true surround).
Looks like your PM42A450 has stereo analog output which is what you'd need to use for the x-530s.
So I assume you'll want to have it hooked up for 5.1 sound from the PC, eh?
That means that you're either going to have to get an audio switch (if you don't keep your computer on all the time), or you'll want to keep the speakers plugged directly into the computer and then run audio from the audio out of the TV to the "line-in" on your soundcard. This is assuming that your soundcard or integrated sound has line-in capability while in 5.1 mode.
I can't check your rig since the link is broken.
http://forums.anandtech.com/me...y=y&keyword1=rig+links
I'm in the process of downloading the manual for the TV, but I would hope it has the ability to take audio off HDMI and then spit out analog for you to use.
If not, worst case is you'd have to use component for the cable box or something.
EDIT: I looked at the manual. I got the impression that hooking up via HDMI will work for you (didn't see a not in the area of hooking up an external system via analog audio meant not getting sound from HDMI audio inputs). I'm not sure if your cable box can output audio over HDMI though since I'm not very familiar with the different models out there. If it has HDMI for the video but not audio, then you can hook up to HDMI 2 and use analog for the audio.