I believe the answer is yes. Once you put enough energy density into the electric field, you'll be able to produce particle pairs. I think they have seen this issue with ultra-intense lasers in vacuum.
It's sort of like the asymptotic freedom in strong interactions. You can pull the quarks farther and farther apart, but you are just putting more energy into the gluon field. At some point, the gluon field has enough energy to pair produce a couple new quarks, and you end up with 4 quarks instead of 2.
If you squish two electrons together, you'll push a ton of energy into a small space, and this will produce new particles. This is the basis behind particle accelerators. LHC does this but with protons and anti protons. The old version of LHC was called LEP and they did this with electrons and positrons.
If I was to ballpark the answer, I'd say something like:
mass of an electron = 0.5 MeV
mass of electron + positron = 1 MeV
If we give them each a bit of energy, say 1kV, the deBroglie wavelength of each is about 1 nm.
The electrostatic energy in an E field per unit volume is given by:
u = 1/2 (epsilon) |E|^2
So if you set u = 1 MeV in a spherical volume of 1 nm radius, you can look up epsilon and compare that to the E field produced by two electrons 1 nm apart. Keep moving the electrons closer and closer until the E field energy density is greater than 1 MeV per nm^3 or so.
I don't know if this is exactly right, but it'd probably get you in the ballpark.