Yeah on my longest wire run, which is about 25', maybe a little shorter... I had it running across the floor underneath my door in my bedroom (in-between the two sections of carpeting). Used to have it covered with duct tape so I wouldn't trip over it, but after removing it a few times because I take my surround setup to school with me now, I didn't tape it back up.
Sadly, the dog, when she was still somewhat of a puppy, had a thing for chewing anything. Shoes, stuffed animals, comforters (really likes that polyfill), and whatever else you can imagine... including that speaker wire mentioned above.
My longest run, she had to chew up. Ugh. Little bitch.
She chewed it towards the end with the speaker attached. But I didn't have any cable, and I still haven't replaced it half a year later. I might do that this summer though, just buy a new 25' spool and use that as the wire run.
But I just took the two halves, separated the + and - halves some so I could work with it, stripped the plastic and twisted the wire together, then covered each with black electrical tape. Has worked beautifully, and haven't noticed any impacts during listening. Though it got snagged once and separated, but quickly repatched, even using the same tape, and buried it underneath the cut of carpet we have here at school.