: Start out going NORTHWEST on W 43RD ST toward 8TH AVE. 0.2 miles Map
2: Turn LEFT onto 9TH AVE. 0.3 miles Map
3: Take the LINCOLN TUNNEL ramp toward NEW JERSEY. 0.1 miles Map
4: Merge onto I-495 W. 0.9 miles Map
5: I-495 W becomes NJ-495 W. 3.2 miles Map
6: Merge onto NEW JERSEY TURNPIKE S / I-95 S via the exit on the LEFT toward I-280 / NEWARK / I-78 (Portions toll). 3.9 miles Map
7: Merge onto I-280 W via EXIT 15W toward NEWARK / KEARNY (Portions toll). 17.4 miles Map
8: Take the I-80 W exit on the LEFT toward DOVER / DEL WATER GAP. 0.5 miles Map
9: Merge onto I-80 EXPRESS LN W. 2.1 miles Map
10: I-80 EXPRESS LN W becomes I-80 W (Portions toll). 726.9 miles Map
11: Merge onto I-80 W via EXIT 21 toward IN-51 S (Portions toll). 169.4 miles Map
12: Merge onto I-280 W. 26.6 miles Map
13: Merge onto I-80 W via the exit on the LEFT toward DES MOINES. 1223.4 miles Map
14: Merge onto I-80 W via EXIT 311 toward RENO / S.L. INT'L AIRPORT (Portions toll). 734.2 miles Map
15: Merge onto US-101 N toward MISSION ST. 0.7 miles Map
16: Take the US-101 N / MISSION ST exit toward VAN NESS AVE / G G BRIDGE. 0.1 miles Map
17: Turn SLIGHT RIGHT onto MISSION ST / US-101 N. Continue to follow US-101 N. 0.3 miles Map
18: Turn RIGHT onto MARKET ST. <0.1 miles Map
19: Turn RIGHT onto 11TH ST. <0.1 miles Map
20: End at San Francisco, CA US Map
Total Est. Time: 42 hours, 58 minutes Total Est. Distance: 2911.01 miles
Straight from Mapquest. You can easily use the right, right, right to get onto 9th ave. If you don't count merging as a turn, which it really isn't you're just about there. There are a couple of other steps that may require some work at avoiding a left but shouldn't be too much of a problem. The biggest problem would be getting back on the freeway after stopping to get gas, etc. Solution - Never get off the highway. Drive a van and haul enough gas, food, etc. to make the entire trip including pulling a trailer if necessary. Share the driving duties with at least one other person. OK so it looks like it could be done relatively easy.
Mapquest