You can, but it is not a good idea. This has nothing to do with being able to disable ECC in BIOS. ECC memory will generally have 9 devices per side while non-ECC memory devices have 8 per side (x8 devices). Modern chipsets require advanced memory initialization routines (in BIOS) that program drive strengths based on how many devices are present on the memory bus. Mixed memory (ECC and non-ECC) are not accounted for in this algorithm, so improper drive strengths can be programmed. Many of today's chipsets are not certified for mixed memory types for this reason, so if you are seeing system lockups, this could well be the problem.