I believe the only difference is that the four sticks were specifically tested to work together whereas two separate dual packs may or may not work well together. They can definitely work as 2 duals.
Given that any ram, by definition of meeting a given spec, will work find with any other stick rated at the same spec. No extra testing needed as that is why specs / specifications exist.
Now if it was a high end ram tested to run at speeds inexcess of the standard spec then I can agree, but then the same process of testing binning occures for the faster speeds resulting in batching of ram without testing the ram together as a set.
So once again, if buying ram of the same timings/specs, it does not mater if they came in the same box as each indivual needs to meet the advertised spec level. Otherwise you can return it can get another one as the product is faulty / does not work as advertised.
With all that taken into account, expecting the ram to be tested to work together is just marketing talk to convince you it is a better way to buy your ram. If anything, a pack should be cheaper than the individual units on the grounds of less handeling alone, but like that has ever been a reason for manufactures to pass on lower costs.
One 4x4GB pack I was looking at last month was cheaper than 2 dual packs which was cheaper than buying the sticks individually. Unfortunitly for some brands, that is not true, they still ask more per set than for individual ram of the same timings and claim "testing" as the reason. It is only marketing of the same goods as I see it. Each to their own though in the end.