I think it depends on the controller, the BIOS and the "mode" (AHCI versus RAID).
  
 On an older non-UEFI motherboard, an AHCI drive will be thrown up as removable or hot-swappable in the system try "safe removal" icon pop-up.
  
 So far, I've tried to change this behavior to my liking, but -- "no cigar."
  
 For my own systems -- workstation and server -- it doesn't bother me.  But Mom's boot-system SSD appears in the pop-up and could be "removed" by accident.
  
 Mom has been known to click on "stuff" by accident.  I have to continually reset her e-mail browser to a view that she's used to.  At her age, she needs more help with her "personal" computer than most, even having used one for two decades.
  
 The problem I face with that:  I installed a hot-swap tray for certain occasional backups of her system.  We use thumb drives.  I can remove the icon, but then I may need it.