I was around then and ESX 3 was flaky as on intel as well........ We ran just as much opteron as we did Xeon during those days, dont remember any difference in platform stability. The fact they sold everything they could make while being more expensive then Xeon's (atleast in australia) shows that no one else really had these problems.........Some of us have been around long enough to remember AMD's Opteron product line, and how unstable it was compared to their Intel brethren. It was particularly flaky with VMWare ESX early on, which would explain why no CTO in their right mind would use a first generation EPYC processor as a production hypervisor.
Personally, I'd buy one to run dev/test workloads and see how it performs there. If it works out there for a year, THEN we can buy some for production.
I dont know why people are pretending this is all new to AMD, IF is the continuation of hyper transport, The topology of a 2 socket EPYC is the topology of a 4 socket mangny-Cours/BD (https://pdos.csail.mit.edu/6.828/2016/lec/AMD.pdf).
Intel has a complete new uncore for scailable family, do you recommend the same approach?