From a logistical standpoint, Intel and McAfee are right down the street from each other in Santa Clara so it's not going to be too hard to integrate outside of possible culture differences. Intel doesn't make that many acquisitions, or acquisitions that are big enough that everyone would hear about them. The only thing that doesn't make sense to me is that AMD acquired ATI a couple years back...that kind of makes sense as they're both in business in computer hardware. Intel being a hardware company and MFE being a software company, doesn't make as much sense.
From a profitability standpoint, Intel must really be thinking about business/enterprise users as I think MFE makes most of its revenue from that line of business, as opposed to its consumer line.
Wonder if anybody is looking at buying Symantec. Their market cap is only ~$3B more than MFE but their revenues are ~4x MFE's.