I have a Q600, which is a Q500 with a different bezel, and I experimented with a Radio Shack digital thermometer. Intake seems to be better on my box. If you do just one blowhole, centering it on the AGP card is a good way to go, it will ventilate the upper cards and also feed air into the CPU area. Two 120mm's sounds like overkill to me, but if you have tons of drives in the 5.25" bays you might put a 120mm as a top-rear exhaust or a top-panel exhaust blowhole to keep the upper section of the case cool. The Q500 has that "bottleneck" between the motherboard area and the upper area, and it's known to get hot with lots of drives in the top. Personally, I moved my power supply to the top rear and eliminated the bottleneck.