As always with these types of questions, the answer is "it depends". I see you have no credit card debt or high-interest loans, so that eliminates one answer.
If you are savvy with investments, then you might consider investing your money and try to outperform the interest on your house.
If you are not good with investments, think about what other expenses you might have in the future. Remember, when you pay off the house, that is a LOT of money tied up that you have no access to (unless you take a HELOC or Home Equity Loan out). For example, how old is your car, your roof, your windows, your furnace, etc. If you foresee any major expenses coming up, you might want to split the money between mortgage and savings.
If you are not good with investments, and have no foreseeable large expenses in your future (or already have a nest-egg set aside for that), then by all means, pay that house off and enjoy mortgage-free existence!
One last thing, I'm not sure if these laws are still in effect, but at one point if your "acquisition indebtedness" goes to zero (which it does when you pay off the mortgage), you were limited to a $100K interest deduction cap. If this is still the case, that's another factor to consider when paying off the mortgage.