Are all of your friends and family rich? If not and you don't want to pay for a lot yourself you will probably want to keep it within driving distance of where most guests live. I recently heard of somebody who rented out a whole bed and breakfast place for the weekend. There were something like 15~20 rooms and some cabins and they had the dinner, ceremony, reception etc... all there. Other friends have rented out a floor of a hotel by the beach etc...
But if your friends and family are loaded then several friends have been to the Sandals all inclusive resorts for their honeymoon and the had a great time. A cruise is also a good idea.