Due to my experiences with the AM3 chipsets (SB7xx, SB8xx), it would have to be a really compelling argument/usage scenario for me to consider AMD as a platform choice.
Across multiple boards/computers:
1) I saw issues to do with certain combinations of SATA ports not wanting to be used in IDE mode (maybe AHCI too)
2) My last AM3 board had a tendency to do weird things on AHCI if various optical drives were accessed in certain ways (weird enough to cause the optical drive to stop working until reboot, and for Windows to take ages to shut down because of AHCI difficulties).
3) USB filter drivers across two generations of chipset, 'nuff said.
4) Broken default RAID1 configuration; pretty much guaranteed to fail in about 6 months (documentation doesn't make any recommendations about what settings to use either), very iffy RAID drivers, updating to the latest was a risky gambit.
5) Iffy AHCI drivers, the last set of 'up-to-date' drivers I tried on SB750 would cause up to 30% CPU usage on "system interrupts" (a less iffy driver would cause a more normal ~1% even under load).
Over a three year period of using AMD chipsets for PC builds, I encountered at least one weird chipset-related issue a year. Since changing back to Intel, I've had one weird board-specific issue in four years.
PS - I'm not saying that these are issues that most people experience. The SATA port weirdness is down to pot luck (maybe Asus AMD boards too, but I doubt it), very few people use desktop RAID, most people will probably use the same AHCI driver on their single AMD box unless they have AHCI issues, etc. I just think that AMD's chipset driver QA leaves a lot of "room for improvement", to put it nicely.