Disable SSDP Discovery service as well, this will have the added bonus of closing a port on your system.
You may want to get a hosts file like MVPS (updated with hostsman) for blocking some common ad/malware sites, since sometimes infections can spread by something as benign as viewing a malicious jpeg (usually hosted on a third-party ad site, though I heard NBCNews.com got infected a while back). Even with AdBlock+, security in layers might help. If you do this, disable the DNS Client service too, this will help the system boot faster if you're using a hosts file with a lot of entries and also make it so you are less vulnerable to DNS cache poisoning attacks. Try setting your DNS servers manually so you don't pick up different DNS servers depending on which wifi you are connecting to, you can use Google Public DNS (8.8.8.8 and 8.8.8.4), this will also let you check these values from time to time to see if it's been tampered with. Disable IPv6 unless needed (some third-party VPN solutions will require it)
At work we use bitlocker, but that only really helps if you lose your laptop or something crazy like that, i.e. if they try to physically remove your HDD or boot from a live OS to inspect the contents - doesn't help once you're logged in at all. Make sure you're using a BIOS password as well, as someone else suggested. To set a BIOS password at boot time you have to press a different hotkey depending on the make/model of your system (usually DEL or F1 or F12 at boot will bring up the BIOS screen) then from BIOS set an administrator password and set boot order of the HDD to primary so that people can't boot from a CD first (unless you manually enter the password and change that in the future).
The most important rules... don't visit lots of random websites, never open suspicious attachments or documents from untrusted sources, limit your attack surface by not installing too many third-party applications like Adobe, Flash or Java unless absolutely required (disable the browser plugins whenever they are not in use), keep everything up to date, scan frequently, and keep a watchful eye on your system's processes/network activity!