A few years ago, I did some research on this (w/ 7200 RPM drives), and determined that it really wasn't worth it for me to go RAID 0. From what I remember, with 2 drives in a RAID 0, the write speeds were a few MB's / sec faster, but the read speeds were a few MB's / sec slower. If you went with a 4 drive RAID 0, you saw a significant increase in write speeds, as well as an even more obvious slowdown in read speeds. I decided for myself that RAID 0 wasn't worth it for me, but I'm not a heavy gamer, videophile, etc. If you use your PC for a specific purpose or application, this should be your determining factor in deciding to go RAID 0 or not. That, and your budget. For me, I don't want to waste any HD space or extra money just to get a few extra MB's / sec write speeds.
P.S. I looked over an old storagereview article concerning RAID 0, and a statement they made concerning this configuration, in comparison to running a single HD was this:
"If we compare the performance of the single HDD and RAID0 array, the latter will turn out faster when working with larger files (e.g. in SoundForge), no matter what firmware the drives have. When working with smaller files, the RAID0 array doesn't have any advantage over the single hard drive."