totaly depends on the apps, the larger cache helps hide 7200rpm hdds poor seek times so it makes your system feel snappier, but for STR intensive apps it make pretty much no difference at all, so if you doing raid 0 or some forms of AV editing where seeks don't really matter and STR is king it won't make that much off a diff. However in everyday desktop usage there is quite a noticible difference and I would always suggest the 8mb buffer drives of the 2mb ones esp. since the price difference is so small.