I've done it a few times two 42" Lcds and a 42" Plasma.
Its pretty easy, couple of suggestions.
If you have weird spacing on your studs, and want extra support cut and paint a pieces plywood for the mount to go on. Use lag bolts through the plywood to the studs, then attach the mount to the wood. This gives you more options when trying to center the TV.
If your unsure about finding studs, tap a finishing nail into the drywall, if it stops, you have a stud.
Take the time to do it right, and make it look neat, it will be there a for years.