That would be 26 letters lower, plus 26 letters upper, plus 10 numbers = 62 chars
62^8 = 218340105584896 possible combinations
It really depends on what you are cracking. Zip password crackers can try 4.5 million/sec, Excel crackers are about 230,000/sec. From what I've seen, OS crackers can only go about 2k/sec. I might be wrong, so someone correct me.
However, other kinds of password crackers just replace your password with something else. if someone has physical access to your machine, it won't matter how strong your password is. They can just boot into a CD-os, and replace your password hash with one that matches a simple one like "abcde."
Also, the easyest way to make a brute force crack hard is to have your passwd start with a letter at the lower half of the alphabet, because most start at "A" and go down. Because if your passwd is AAAAAAAA, it doesn't matter that it has to spend fifty years cracking if it can get it right on the first try.