At least our climate does not allow for spiders that can catch and eat a bird.
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If I lived in a place like that, or else one of the regions that's got fun things like brown recluse spiders, scorpions, and turantula hawks.....yeah, I'd definitely be looking for that hermetically sealed house.

That, or else have the thing lined with gamma ray emitters, and sterilize the shit out of the entire house on a daily basis.
I don't usually mind spiders and such all that much, but when they're sufficiently venomous that they can cause gangrene or fatal bites...that's about where I draw the line.
Oh, and another bunch of things I got to experience back at my parents' house, but not so much in Erie: Horse flies and deer flies. They're quick things that land and bite in a hurry. They don't try for stealth either, like a mosquito - their method is to slice open your skin so that you start to bleed, and then lap up the blood. Usually they'll zip in circles around your head and land on a side that
doesn't have eyes on it, and attempt to get a meal.
Luckily there weren't many of the huge variety of horse fly around - there are a few types that get to be more than an inch long.