That's the beauty of the Internet and online multiplayer--you have the opportunity to play strategy games against real opponents and not just mindless AI.
I wonder if there's an economic model behind that...
Episodic content, where you can only access the next episode by playing as an opponent to someone playing an earlier episode (so no spoiling, and you know some of the challenges). Similar to Shogun2's drop-in battle mode, only for an action game. Kill the hero, get extra credit, add some matchmaking, and you can limit your AI to the first episode, and only for the first few people.
Combine it with regionally staggered releases (dota 2 release model?) and you may create something that is quite fun and different, at least for a while.
Downside: There will be griefers. You can probably deal with those, by giving opfor scores for accessing certain positional tokens, and players that do not collect these tokens or deal damage to the hero are eventually placed in low priority queues, until their performance improves.
Wait, this thread is about homeworld? Best situation would be a 3D-space action type game in a Homeworld setting. But outlook is bleak.