What is the difference between Microevolution and Macroevolution?
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  Question: "What is the difference between Microevolution and Macroevolution?"
Answer:  Microevolution is an uncontroversial, well-documented, naturally  occurring biological phenomenon. It happens every day. It is the process  whereby preexisting genetic information is rearranged, corrupted,  and/or lost through sexual reproduction and/or genetic mutation  producing relatively small-scale (“micro”

 changes within a population.  Two long-haired dogs producing a short-haired puppy would be an example  of microevolution (we’ll look at why in a moment).
Macroevolution is the somewhat more controversial, theoretical  extrapolation of microevolution that requires the introduction of new  genetic information. It is believed to produce large-scale (“macro”

  changes. An amphibian evolving into a reptile or a reptile evolving into  a bird would be examples of macroevolution. 
Macroevolution is an important concept because Darwinists believe that  it is the mechanism for their idea that all life evolved from a common  primordial ancestor. Since microevolution is small-scale (“micro”

  biological change, and macroevolution is large-scale (“macro”

  biological change, many Darwinists argue that macroevolution is simply  the accumulation of microevolutionary changes over time. Ostensibly,  this is a reasonable extrapolation of microevolution. Darwinists,  therefore, often cite evidence for microevolution as evidence for  macroevolution. However, because macroevolution requires new additional  genetic information, no amount of rearrangement, corruption or loss of  existing genetic information will produce macroevolution. In other  words, no amount of microevolution will produce macroevolution.  Darwinists draw a false correlation between the two. We will now take a  closer look at both microevolution and macroevolution.
Microevolution
We will begin with microevolution. Let’s say, for example, that within  the dog genome there are both a gene for long hair (H) and a gene for  short hair (h). Now imagine that the very first dogs possessed both  genes (Hh). If two Hh dogs bred, half of the Hh from one dog would  combine with half of the Hh from the other dog through sexual  reproduction, and there would be four possible outcomes for offspring:  HH, Hh, hH and hh puppies.
Now let’s suppose that the longhair H gene is the dominant gene and the  shorthair h gene is the recessive gene. That means that when a dog  possesses both genes, only the longhair H gene will be expressed, i.e.,  the dog will have long hair. So, if two longhair Hh dogs bred, the odds  are that they would have three longhair puppies (HH, Hh and hH) and one  shorthair puppy (hh). The two longhair dogs having a shorthair puppy  would be an example of change within a population resulting from the  rearrangement of preexisting genetic information (i.e., microevolution).
If a longhair Hh dog bred with a shorthair hh dog, the odds are that  they would have two longhair puppies (Hh and hH) and two shorthair  puppies (hh and hh). If two shorthair hh dogs bred, they would produce  only shorthair hh puppies. And if this group of shorthair hh dogs became  isolated from the longhair HH, Hh and hH dogs, they would lose access  to the longhair H gene altogether and become an “isolated gene pool.”  When it comes to dogs, isolated gene pools are called “purebreds.”  Likewise, if a group of longhair HH dogs became isolated from the  shorthair h gene, they would be considered purebred. On the other hand,  the longhair Hh and hH dogs would be called “mutts.” Human breeders have  been exploiting this biological phenomenon for thousands of years,  selecting dog couples to mate based on their appearance in order to  accentuate and attenuate traits gradually over time and thereby  introduce new breeds.
Genetic Mutation
Now imagine that, within a longhair Hh population, a genetic mutation  disabled the expression of the longhair H gene, and that mutation was  reproduced over and over again within the population. The formerly  longhair population would become shorthair, not because of the  rearrangement of genes through sexual reproduction but because of  genetic mutation. 
Another important example of microevolution through genetic mutation is  when a population of insects becomes resistant to a certain pesticide,  or when bacteria become resistant to antibiotics. What happens in these  instances is that through mutation the insects or bacteria lose the  ability to produce the enzyme which interacts with the poison. The  pesticide or antibiotic, therefore, has no effect. But the insects or  bacteria don’t gain any new genetic information; they lose it. It is  not, therefore, an example of macroevolution as it is often  misinterpreted, but of microevolution. As biophysicist Dr. Lee Spetner  explains, “All of the mutations that have been examined on a molecular  level show that the organism has lost information and not gained it.”  (“From a Frog to a Prince,” documentary by Keziah Films, 1998)
Macroevolution
Now let’s look at macroevolution. Darwinists believe that all life is  genetically related and has descended from a common ancestor. The first  birds and the first mammals are believed to have evolved from a reptile;  the first reptile is believed to have evolved from an amphibian; the  first amphibian is believed to have evolved from a fish; the first fish  is believed to have evolved from a lower form of life, and so on, until  we go all the way back to the first single-celled organism, which is  believed to have evolved from inorganic matter. [The acronym to remember  is FARM: Fish to Amphibian to Reptile to Mammal.] 
The very first single-celled organism did not possess all of the genetic  information for a human, so in order for humans to have ultimately  evolved from a primitive single-celled organism, a lot of genetic  information had to be added along the way. Change resulting from the  introduction of new genetic information is “macroevolution.” 
The reason why macroevolution is controversial and remains theoretical  is that there is no known way for entirely new genetic information to be  added to a genome. Darwinists have been hoping that genetic mutation  would provide a mechanism, but so far that has not been the case. As Dr.  Spetner again explains, “I really do not believe that the neo-Darwinian  model can account for large-scale evolution [i.e., macroevolution].  What they really can’t account for is the buildup of information. …And  not only is it improbable on the mathematical level, that is,  theoretically, but experimentally one has not found a single mutation  that one can point at that actually adds information. In fact, every  beneficial mutation that I have seen reduces the information, it loses  information.” (Ibid.) 
Creation vs. Evolution
When Creationists say they don’t believe in evolution, they are not  talking about microevolution. They are referring to macroevolution.  Microevolution is a credibly observed scientific phenomenon. What  Creationists do not believe in is Darwin’s macroevolutionary  extrapolation of microevolution. Unlike microevolution, there is no true  scientific evidence for macroevolution, and, in fact, there is  significant evidence against it. The distinction between microevolution  and macroevolution is, therefore, an important one for those interested  in the creation-vs.-evolution debate.