I'd go back to the registry (regedit.exe) and go to the following key:
HKEY_LOCAL_MACHINE\Enum\SCSI
Now, in the SCSI section you should find your cdroms/cdrw's listed. Make sure you don't have any remnants from previous cdroms in there...I just found one in mine for a cdrw that I had replaced with a newer Plextor.
Fortunately it wasn't causing a problem, but older entries in the Enum section CAN cause problems if allowed to remain. Enum is where Windows lists everything it detects hardware-wise.
If you do find an entry for an older cdrom, delete it's master key. In other words, delete the key that mentions the cdrom's name. Each key has subkeys that start out with "MF&CHILD blah blah blah"...don't just delete the subkey(s)...delete the master key for that device.
You don't have to worry about anything you delete from the Enum section of the registry, as if you deleted something that actually existed, Windows would merely redetect it again at next boot. The only issue you might have is with a device that requires drivers that Windows doesn't natively have, in which case, you'd want the driver disk handy.
If you DON'T see an entry for an older cdromm/cdrw, but DO see the Plextor, I'd delete the Plextor entry, and let Windows redetect it at next boot up.
Do take the advice of others who suggested doublechecking the bios for your IDE settings and the drive itself for master/slave. Also, check config.sys, if you have it, and make sure there's no "Lastdrive=" entry in it which might be limiting your drive letters. If there is, make it Lastdrive=z"