As already mentioned by
@Elixer you should be recommending the business give this a bit of thought. As soon as you involve a business that is managing other customer's data, you may be putting yourself at risk with compliance. Even if not looking from a Business perspective. For instance, people will mention Carbonite, Backblaze, and Crashplan as affordable options, but
all 3 have
explicit terms against commercial use of the the home versions. So you should be evaluating the Small Business or Business versions of each option. Doing otherwise is not only dishonest, but can, again, get you in hot water when auditing comes around.
The fact that you're asking about the motherboard and CPU as points for compatibility has me slightly concerned that this may be getting evaluated from the wrong perspectives. You shouldn't be looking at this from a compatibility perspective, but a compliance perspective. In fact, it would make me question if any of this data is being handled properly if such a backup system on what sounds like a commodity system is just now being evaluated.
So as mentioned above. Really any generic hard drive + Cloud (I like Crashplan myself) is a great base backup system
for home use. As soon as customer data is involved, I would tread very carefully, and be cautious about how much advice you give your compatriots if you aren't certain they haven't worked their data strategy out. Friendly advice is one thing, but when business is involved, the laws are cold, and not necessarily fair.