While this is OK if you want to shoot your 45 cheaply for fun, I don't think it's good advice for someone who's planning on using a gun as a last resort for self defense.Recommendation: Buy a .40 or .45 that you can get a barrel change out kit for. Then make it into a .22 and plink away at the range with it. Once you're done put the original barrel back in and take it home. Best of both worlds. Most .45's can be easily converted.
One shot may not always stop someone - you need to be ready for that followup shot. If you've been plinking with low-recoil 22LR and have only put a magazine or two of real 45ACP through your gun, you may lack the ability to recover from the recoil and make a second shot.