John Irving books are really good. Lots of character development which chicks seem to like. I'd recommend Cider House Rules, Prayer for Owen Meaning, World According to Garp, or the Hotel New Hapshire. All of these are solid books and well written.
Then, there's Douglas Adams and Hitchhikers Guide.
Donald Westlake writes good crime books about losers who never win. Any Dortmunder (he's the main character and will be listed in the book summary) book is a quality read and well worth the time you'll put in.