I've got several cases running on slight negative pressure and dust is not a big problem though once a year I have to blow out the inside of the case, i Have cats too.
Creating a faster moving draft will not necc. cool more efficiently due to the amount of bypass you end up with. Yes the expansion is minimal but in all case just as others have stated it is still more effiecient to draw air out, the inflow is best for turbulance and in most cases the intake is mounted away from the from panel an is not really sucking in from outside but happens to be where most of the intake air comes in. What I've seen is the intake fan blasts air out in a cone thus hitting the walls and bottom of case and upper HD(yes cools lowest drive) and then proceeds to bounce around the case and moves a lot of air at the PCI slots and Video. Ive also observed with streamers that the air hitting the bottom HD accually swings upward and creates an occilation around the dimms and northbridge area. Beyond that point I saw no further benefit as the exhaust draft is working on the area around the cpu and mosfetVRs. With all cases differing slightly, this scenary varies somewhat.
<strong>Flow chamber test!</strong>
If you don't have a window case, use a sheet of plexy to cover the side. Tape 1/8 inch by 4 inch long plastic streamers to the bottom of lowest drive, bottom edge of VGA, one near the top of your dims and one near your northbrige. Just be sure none of them get sucked into your fans. Power up the rig and place the plexy against toe opening. You sould see movement in all the streamers. If not, you may have to tidy ups some cables especially those flat ATA cables (fold them in half along the length to reduce size. make sure none are hanging below the HDs, zip tie them to the side if they do. Stuff extra cables on top of floppy or CDRom drive away from the warmer drives and away from the MOBO airspace.
Improve Airflow and Quieter Fans, cut out punched metal cheese grater slots and lovers, replace with the wire type grills.