Enjoy it while you can, the A-380 will most likely be the last passenger aircraft with four engines, due to economics and advances in reliability.
For example, a typical engine on an A-380 has around 70K of thrust. A 777-300ER can push upwards of 110-115K of thrust. For comparison, an engine on a 737-800 has between 24.5 and 27K of thrust!! These numbers will vary slightly depending on manufacture of engine and its "firmware" so to speak, which dictates max thrust without needing to change more expensive mechanical components.
Back in the day people would be afraid to fly long over water routes on two engine aircraft, but that era is long gone. The 767 was the first twin engine that regularly flew trans Atlantic routes on two, and now the 777 routinely flies trans pacific routes on two engines. ETOP (Extended Twin Engine Operations) rules are adjusted as reliability increases.
For example, an aircraft with an ETOP rating of 180 means it must be able to reach a suitable airport on ONE engine within 180 minutes. This is why some trans-pac routes don't follow a perfect great circle line. For awhile, some airline (I think PanAm may they R.I.P.) maintained a small island airstrip in the Pacific to shorten their flights and for refueling if needed.
There is also a school of thought that two engines are actually safer since there are half as many engines to go wrong. Last I saw statistics bore this out, or was close enough to be negligible.
I have had the pleasure of standing about 100 yards of a GE90-115B spool up to full thrust. The sound it makes and the feeling of sheer power is indescribable.
Also, the 777-300ER is actually slightly LONGER than an A380 at 242.2 feet, vs. the A-380 at 239. And the 747 will ALWAYS be the Queen of the Skies. :Colbert: