vizualgirl, thats normal!
You are gonna hear hisses, and "CD-sounds" (ie u can literally hear it spinning). Just go to volume control, and mute the CD. Unmute when you gonna actually use it. There's also gonna be mic noise, or line in noise, as the inputs are sensitive, and they pick up the EM impulses from your pc. Just mute mic, line-in, and cd-audio. Unmute them, if you need them. DO NOT DISCONNECT ANYTHING!!! Ofcourse, unless you're bored, and just wanna check out the innards of yo pc, cuz its not gonna change anything. Its like guitar pickups - they always pick up interference from all the electric appliences in your house. Even the remote control!
So don worry, its PERFECTLY normal. And as for "I havent noticed it with my old mobo" - when u reinstalled the audio drivers, the driver jacked the cd audio, line in all the way up.