To be more specific: It is 'indepedent' The filesystem the drive uses and the enclosure are mutually exclusive. It depends on what you plan on plugging the thing into. That is to say, if you plug it into a windows XP box, which can read NTFS, it will work. If you say, plugged it into a Linksys WRTSL54GS, it won't work, because it runs a stripped down linux and can't read NTFS. Same with Macs and older Windows 9X installations.