it might help in a case or two if running some mods. really though you will need to be running sli at that res to run settings that will go beyond 2gb of vram.
You're definitely more comfortable with having more video ram onboard. There are already games that are starting to use
more video ram when available. If not for more FPS, then for less frequent disk access. The prime example is BF3. More games to follow. If
I were in the market for a high-end card, I'd get at least 3 gigs, even though... 2 gigs is enough for todays games.