The long crankshaft in an inline 6 does pose problems. it flexes more, due to the power pulses, than a v6. Ford's 200 countered that problem by using 7 main bearings, and borrowing some stiffness from the block. inline 6's are usually limited to a lower RPM than a v6, given equal cost and technology. That is another reason V6's are prevalent, automakers look to cost first. When it comes to maintenance, the inline 6 wins, hands down. Distributors, starters, alternators, water pumps, oil filters, etc, are more readily accesible on a straight engine.
I was able to change oil on my '66 mustang without going under the car! I could reach both the drain and filter from above, and use my boot to move the pan.