I use my Intellimouse Explorer for gaming, and I have never had a problem. In fact, it's been more reliably accurate than any ball mouse I've ever used. I use a Trackball Explorer for everything else, since I have tendonitis of the wrist (too much mousing), but I just move it over and grap a hold of the mouse for gaming. My girlfriend and I will sometimes get in pointer wars, though...when she'll grab the mouse to click on something, while I've got the trackball trying to go somewhere else...hehe.