My brother had the exact same problem in one particular spot... Every time he would try to enter an spot where the game would "save" and "Load", the game would crash with a GPF.
Finally, he just started all his games from scratch (deleted all saved games). That cured it.
We think what happened is that he did a couple of things "out of order." In that particular level, he was supposed to first get some sort of vaccine or virus and then free some hostages at the subway. The first time, he first freed the hostages and then got the vaccine/virus. By restarting the level and doing it right, the problem was solved.
It seems to me that the game does not like adjustments of plot. A sign of poor development in my opinion. (Don't get me wrong, it has a good plot and nice graphics. Just not very "idiot proof".)
P.S. We tried reinstalling, uninstalling and installing, turning graphics mode to software, and playing with detail/sound settings. This was the only thing that worked.