Decongestant nasal sprays: oxymetazoline (Afrin) vs xylometazoline (Otrivine)

omega3

Senior member
Feb 19, 2015
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For those people who have used decongestant nasal sprays with oxymetazoline (Afrin) or xylometazoline (Otrivine), what's the difference in duration of effect and also, which one gives the most rebound swelling when using for multiple days?

I only have used a phenylefrine nasal spray and it only works for like 3 hours.

Thanks.