39. A novel approach for computational alanine scanning: application to the p53 oligomerization domain.
L.T. Chong, W. C. Swope, J. W. Pitera, and V. S. Pande.
Journal of Molecular Biology (2006)
SUMMARY: Roughly half of all known cancers involve a mutation in a single protein: p53. P53 serves to protect us from getting cancer; when p53 fails, one often gets cancer. We have developed a new method for predicting how mutations in p53, a protein central to cancer, would impact p53. This new method is naturally suited for distributed computing and can predict several mutations found to date.