ABSOLUTELY NOT
Did you insert the bolts into the holes and thread the nuts on just short of finger tight prior to tightening?
How far off is it? Has the vehicle been hit before? I would loosen all of the bolts until they're only held in by ~3 threads and then see if you can make the last one line up.
Sorta what I'd suggest, although if I'm not mistaken, his CR-V uses welded nuts on the frame for hitch mount. So he's not simply putting a bolt through a hole and putting a washer/nut on the other side and tightening, he's threading into a nut that's immobile. If he has to tilt the reluctant bolt too much to even access the hole, it probably won't thread worth a darn.
I too wonder if the frame's been tweaked (accident) or the hitch isn't fabricated properly...it happens.