Crohn's Vaccine

Circlenaut

Platinum Member
Mar 22, 2001
2,175
5
81
Has anyone with Crohn's checked out these two sites?

http://www.crohns.org/index.htm

http://freeola.com/crohns.php

I've been reading some of these articles and it's pretty convincing. All this time I've been told by my GI that Crohn's is an immunological disease and he's been pushing down my throat immunosuppressants. Sounds like current treatment is the opposite of what it should be. Jeez making a a person with an active infection take immunosupressants is insane! I understand it gets ride of the symptoms but it would make the infection worse and possibly lead to complications, who knows.

Also this looks very promising at bridging the gap between the immunological and the infection camp.

Look up some videos on Profesor John Hermon Taylor's lectures on youtube.

Anyways as Peter Griffin would say "Why are we not funding this!"
 

BoomerD

No Lifer
Feb 26, 2006
66,262
14,690
146
Because no one famous has come out in support of funding it?

It's not a commonly known disease/disorder so there's no big public push for funding.

AFAIK, I've never known anyone with it...so why would I support it? (see my point? )
 

rasczak

Lifer
Jan 29, 2005
10,437
23
81
Originally posted by: BoomerD
Because no one famous has come out in support of funding it?

It's not a commonly known disease/disorder so there's no big public push for funding.

AFAIK, I've never known anyone with it...so why would I support it? (see my point? )

it's hit home for me once already. my stepmom has had it for a while.
 

Circlenaut

Platinum Member
Mar 22, 2001
2,175
5
81
Originally posted by: SunnyD
.

This is actually a new type of vaccine targeting the bacteria's DNA. What they do is take MAP DNA, insert it into Ad5 and MVA virus (I'm assuming some kind of adenovirus) and inject that into your body. The immune system detects that as foreign DNA and initiates a more effective immunological response. When I took advanced cell bio I remember reading articles doing the same thing in developing a similar TB vaccine.

 

Circlenaut

Platinum Member
Mar 22, 2001
2,175
5
81
Originally posted by: BoomerD
Because no one famous has come out in support of funding it?

It's not a commonly known disease/disorder so there's no big public push for funding.

AFAIK, I've never known anyone with it...so why would I support it? (see my point? )

You could say the same thing about a lot of diseases out there. I don't know anyone personally with MS, should we stop MS funding? Hell I don't know anyone with AIDS or HIV infection, should we stop funding that!? The fact is that there are millions of people out there in the world with Crohn's. It's more common than you think.
 

LeonarD26

Senior member
Feb 12, 2004
826
1
71
It's a terrible disease.

I've had ulcerative colitis for about 5 years now and the symptoms are very similar..... my docs diagnosed me with Crohns at first....

 

BrokenVisage

Lifer
Jan 29, 2005
24,771
14
81
Originally posted by: Pippy
Originally posted by: SunnyD
.

This is actually a new type of vaccine targeting the bacteria's DNA. What they do is take MAP DNA, insert it into Ad5 and MVA virus (I'm assuming some kind of adenovirus) and inject that into your body. The immune system detects that as foreign DNA and initiates a more effective immunological response. When I took advanced cell bio I remember reading articles doing the same thing in developing a similar TB vaccine.

That's all well and good but I don't believe you addressed his statement. :p
 

BoomerD

No Lifer
Feb 26, 2006
66,262
14,690
146
Originally posted by: Pippy
Originally posted by: BoomerD
Because no one famous has come out in support of funding it?

It's not a commonly known disease/disorder so there's no big public push for funding.

AFAIK, I've never known anyone with it...so why would I support it? (see my point? )

You could say the same thing about a lot of diseases out there. I don't know anyone personally with MS, should we stop MS funding? Hell I don't know anyone with AIDS or HIV infection, should we stop funding that!? The fact is that there are millions of people out there in the world with Crohn's. It's more common than you think.

You're ignoring my point. MOST people are unfamiliar with Crohn's disease, and unless/until they actually know someone with the disease, they're likely to be less supportive of giving money to help.

MS is a very well known disease. People have been exposed to a wide variety of fund raising and advertising for more than 50 years.

AIDS? dontcha know? That's GAWD's punishment for permitting the them thar gays to exist! :roll: [/westboro baptist rant]
 

SunnyD

Belgian Waffler
Jan 2, 2001
32,675
146
106
www.neftastic.com
Originally posted by: BrokenVisage
Originally posted by: Pippy
Originally posted by: SunnyD
.

This is actually a new type of vaccine targeting the bacteria's DNA. What they do is take MAP DNA, insert it into Ad5 and MVA virus (I'm assuming some kind of adenovirus) and inject that into your body. The immune system detects that as foreign DNA and initiates a more effective immunological response. When I took advanced cell bio I remember reading articles doing the same thing in developing a similar TB vaccine.

That's all well and good but I don't believe you addressed his statement. :p

No, he did. I just realized it before he finished posting it.
 

Gibsons

Lifer
Aug 14, 2001
12,530
35
91
Originally posted by: Pippy
Originally posted by: SunnyD
.

This is actually a new type of vaccine targeting the bacteria's DNA. What they do is take MAP DNA, insert it into Ad5 and MVA virus (I'm assuming some kind of adenovirus) and inject that into your body. The immune system detects that as foreign DNA and initiates a more effective immunological response. When I took advanced cell bio I remember reading articles doing the same thing in developing a similar TB vaccine.

They aren't really targeting the bacteria's DNA. The idea is to get some host cells to mimic the infection, using the virus as a vector. Cytotoxic T cells should then develop which recognize the infection through peptide presentation in MHC class I and kill the infected cells. It could work, but there are good reasons to suspect it might not. A similar approach failed for HIV.
 

MovingTarget

Diamond Member
Jun 22, 2003
9,002
115
106
Originally posted by: richardycc
because it is more profitable to treat the disease than to cure or prevent it.

This. Perhaps I'm a bit of a pessemist though. Chron's disease sucks bigtime...
 

Bucks

Senior member
Jun 23, 2004
923
4
81
I've had Ulcerative Colitis for about 4 years. As LeonarD26 mentioned, UC is basically the same thing as Crohn's, but the ulceration is limited to the colon/large intestine, which makes it curable. Crohns can be anywhere in the digestive tract. After suffering years (medication including Prednisone and Remicade lost their effects) and my intestinal lining was worn to the point where it was leaking blood indefinitely, essentially causing internal bleeding, I had step one of three surgeries a few weeks ago. It is referred to as J-Pouch surgery. This first surgery, I had my colon/large intestine completely removed. I currently have an ileostomy pouch, which basically I shit in, as my small intestine protrudes from my abdomen area (next to my belly button). In a few weeks, I will have surgery number 2, where they open me back up and use part of my small intestine to form a "J-Pouch". This will act as a holding area for stool which would eventually allow me to have normal bowel movements. Surgery 3, is when they go in and connect everything back up. (They get rid of the ileostomy..yes!). Since having this first surgery, I can eat what I want and even have a few beers ;) .. something I have not been able to do in a long time

Since Crohns can be anywhere in the tract (throat, large intestine, small intestine, etc) surgery is not a cure since you can't remove a lot of those parts, so I am all for this research. Medication wise, it is treated the same as colitis. As mentioned in this thread, not a lot of people are aware of this disease. But it is funny, once you learn of it, you will probably find more people than you know have it.
 

SirStev0

Lifer
Nov 13, 2003
10,449
6
81
The problem with promising research is that all research is promising.

You are looking for a magic bullet. Maybe this is one; maybe it isn't. Someone is funding it and research may prove fruitful. Give it time. You need to realize that for close to 100 years we though stomach ulcers were caused by stress and physiology and that no organism could survive the stomach. We were wrong. See H. Pylori.

Crohn's is one of those disease that we don't really 100% understand. We think it is an autoimmune disease. We know that autoimmune antibodies are in the body when you have it. Immunosuppressants are helpful. We don't know how or why the disease starts and works. It is something we are learning.

Lupus, Rhumetoid Arthritis, Crohns are all lumped into these category. One theory is that certain bacterial infections have proteins that are extremely similar to human proteins. The body recognizes the infection and destroys the bacteria. In doing so the body makes Antibodies to the proteins. Now you are making antibodies that attach to proteins that are almost exactly the same as the ones in our body. A few chances later and now you body is attacking your colon, or your joints, or your skin, or it is just attacking your entire body in general.

This theory is highly researched and we ae learning more and more. Let it run its course. Your best option at this stage is to stick with the tried and true method.

Also, this is the reason why direct to consumer pharm advertising is a bad thing. It gets people like you with little medical understanding questioning everything doctors do. This theory isn't a brand new revelation. It has been around for a while. Hopefully good things will come from it.
 

Circlenaut

Platinum Member
Mar 22, 2001
2,175
5
81
Originally posted by: SirStev0
The problem with promising research is that all research is promising.

You are looking for a magic bullet. Maybe this is one; maybe it isn't. Someone is funding it and research may prove fruitful. Give it time. You need to realize that for close to 100 years we though stomach ulcers were caused by stress and physiology and that no organism could survive the stomach. We were wrong. See H. Pylori.

Crohn's is one of those disease that we don't really 100% understand. We think it is an autoimmune disease. We know that autoimmune antibodies are in the body when you have it. Immunosuppressants are helpful. We don't know how or why the disease starts and works. It is something we are learning.

Lupus, Rhumetoid Arthritis, Crohns are all lumped into these category. One theory is that certain bacterial infections have proteins that are extremely similar to human proteins. The body recognizes the infection and destroys the bacteria. In doing so the body makes Antibodies to the proteins. Now you are making antibodies that attach to proteins that are almost exactly the same as the ones in our body. A few chances later and now you body is attacking your colon, or your joints, or your skin, or it is just attacking your entire body in general.

This theory is highly researched and we ae learning more and more. Let it run its course. Your best option at this stage is to stick with the tried and true method.

Also, this is the reason why direct to consumer pharm advertising is a bad thing. It gets people like you with little medical understanding questioning everything doctors do. This theory isn't a brand new revelation. It has been around for a while. Hopefully good things will come from it.

I am not a regular consumer. Next year I will graduate with a B.S. in biology. I'm partly excited because before, as much as it affects me, I have never really read the literature out there. Granted a BS in biology won't help me understand these articles like a medical doctor would but I feel as if I would understand it much more then the general population.

I'm still skeptical. Lets see how the antibiotic Myoconda fairs in the general population once it's past clinical trials, even if it has a 95% response rate. Also a better assay needs to be developed that better detects MAP. Also, if MAP is the underlying cause of Crohn's then ALL patients with Crohn's should at least have active MAP infections not most. Perhaps this is because of a sensitivity issue using PCR, maybe it's not the cause.

There are a few things I like about this article:

- Mannans have before been proved to cause Crohn's like symptoms in mice
- MAP releases mannans
- The incidence of Crohn's increases at a delay post increased Johne's disease incidence in cattle

I'm just exited because it feels like the data is piecing together and that there hasn't been a substantial improvement in Crohn's care for the last 35 years.

I will keep my eye out on this and anyone out there with Crohn's that can understand the literature critically should too.
 

MrMatt

Banned
Mar 3, 2009
3,905
7
0
Originally posted by: Inspector Jihad
David Garrard has Crohns. He's the only celebrity i know that has it.

was just going to say this. A kid I went to elementary school has it too.
 

Codewiz

Diamond Member
Jan 23, 2002
5,758
0
76
My wife's grandfather had crohns. My wife has had symptoms but my wife hasn't been diagnosed. One of my coworkers had colitis. He recently had his colon removed. He had been on loads of steroids for years to deal with it. They eventually felt he was high risk for colon cancer so they removed it.

Horrible diseases.