It's good to have as it lowers power consumption when your computer is idle.
Short answer: If you're using stock mulitplier and voltages then yes.
But as your using liquid cooling then I'm assuming that your at least running higher volts.
So you can't use cool and quiet as done through AMD's cpu driver.
However, you still might be able to if you use RMclock to manually control multiplyer/volts when your computer is idle/load. If you already have amd's cpu installed, make your power management in control panel is set back to home/desktop before you use rm clock.