It's possible that you have some grit, an eyelash or air pocket under the lens. Take it out, clean it, wet it with solution and put it back in to see if there's any improvement.
Check to see if there is a tear in the lens. It's rare, but sometimes you can get a small corner piece of the lens ripped off. It doesn't impact your vision but it makes the lens very uncomfortable. In this case, replace the lens obviously.
Finally, how often do you clean your lens case? It's a good idea to use hydrogen peroxide and a cotton ball, followed by lens solution and a cotton ball, to wipe out your case. Do this every 1-2 months. Replace the case with a new one every year or if you get a new one with your solution.