Yes, I've changed several spare tires before.
That said, last summer my wife and I were on a stretch of Florida highway that is basically nowhere-land and blew a tire at about 80mph. Could not for the life of me get enough leverage on one of the lugnuts to loosen it and ended up having to call for help. I was literally standing on the wrench and it wouldn't move. At one point I was getting so sweaty that I slid off the wrench and plowed my forehead into the car, nearly falling back onto the highway. That's when I figured I could temporarily forfeit my man card.