Yes,
It works fine with my configuration. Nero works faster and offeres better 1:1 copying for archving of back up CD's. Nero burns quicker in certain configurations.
I use EZCD at times if I can't get something to burn right in Nero.
My configuration below with Nero and EZCD:
Dual P3 1000mhz
Abit VP6
Pioneer DVD ROM 116
Plextor 40/12/40
Leadtek Gforce4 Ti4200 64MB
1GB of Cosair Cas 2 PC150 Memory
309C TX-M 10/100 NIC
SB Live 5.1 Platinum
Generic FireWire 4 port card.
MS Optical Mouse
MS Ergonomic Keyboard